Premium Pharmaceutical Intermediates for Advanced API Synthesis
Looking for reliable, high-quality pharmaceutical intermediates? TUODA supplies advanced intermediates essential for the synthesis of active pharmaceutical ingredients (APIs). Trusted by global pharmaceutical companies, our products deliver exceptional purity, consistency, and regulatory compliance. Partner with TUODA to streamline your drug manufacturing processes and accelerate your path from lab to market.
Explore Our Pharmaceutical Intermediates
TUODA provides premium-quality pharmaceutical intermediates designed for advanced drug synthesis, formulation, and organic transformations. All products meet stringent purity standards and are widely used in APIs, custom synthesis, and contract manufacturing.
Find the right intermediate for your formulation needs below.

N,N,N',N'-Tetramethylethylenediamine(TEMDA)
CAS:35794-11-7

3,5-Dimethylpiperidine
CAS:35794-11-7

4-methylmorpholine(NMMO)
CAS:109-02-4

2-Methyl-3-trifluoromethylaniline(MTA)
CAS:54396-44-0
Industry Applications – Where TUODA’s Pharmaceutical Intermediates Excel
TUODA’s high-purity pharmaceutical intermediates support a wide range of drug development and synthesis applications, including APIs, CNS drugs, antivirals, and custom synthesis. Our products offer exceptional purity, batch consistency, and process compatibility to meet global pharmaceutical manufacturing standards.

API Intermediate Performance
TUODA provides key intermediates critical to active pharmaceutical ingredient (API) production. Our portfolio supports scalable synthesis, ensuring high purity, excellent stability, and consistent performance across formulation stages.

CNS & Antiviral Drug Precursors
We supply essential intermediates widely used in CNS agents and antiviral medications. Our products facilitate precision synthesis and contribute to enhanced pharmacological properties, helping accelerate clinical development timelines.

Reliable Custom Synthesis Solutions
Our intermediates are suitable for both standard and complex reactions. TUODA supports custom synthesis and CDMO workflows, helping customers streamline development for innovative pharmaceuticals and generic formulations.

Regulatory-Grade Manufacturing & Technical Support
With a focus on compliance, every batch meets international regulatory expectations including GMP support. Our technical team offers real-time assistance on solubility, impurity control, and route optimization for reliable pharmaceutical success.
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Enabling the Future of Electronics
Our high-purity precursors support MOCVD and thin-film deposition processes in semiconductor manufacturing. TUODA’s specialized chemical solutions contribute to microchip fabrication, LED production, and next-gen electronic devices, ensuring precision, conductivity, and miniaturization capabilities for a smarter world.
Why Choose TUODA? Your Trusted Pharmaceutical Intermediates Partner
At TUODA, we specialize in pharmaceutical intermediates with a focus on precision synthesis, GMP-compliant production, global logistics, and technical consultation. Discover why leading pharmaceutical companies rely on TUODA.

Precision Manufacturing
Our advanced production technology ensures consistent quality and high-purity chemical formulations.

Reliable Global Supply Chain
Stable production and fast international delivery ensure seamless operations.

Customized Intermediate Formulations
We provide tailor-made Pharmaceutical Intermediates formulations to meet specific industrial needs.

Expert Technical Support
Our team offers in-depth application guidance to optimize production efficiency.
Our Factory Insight
Innovation at Every Stage of Production
At TUODA, our modern manufacturing facilities are equipped with cutting-edge technology to ensure the production of high-quality petrochemical catalysts, chemical intermediates, and feed additives. With advanced automation systems and rigorous quality control measures, we deliver excellence in every product.
From raw material processing to final packaging, our streamlined operations and expert team work seamlessly to meet the dynamic needs of our global customers.
Experience our facilities where innovation meets reliability.
Your trusted partner for quality, efficiency, and on-time delivery.








How to Buy Pharmaceutical Intermediates – A Comprehensive Guide
Pharmaceutical intermediates are critical building blocks in the manufacture of APIs (Active Pharmaceutical Ingredients), influencing everything from purity and efficacy to regulatory compliance. Choosing the right supplier and understanding how to evaluate intermediates are essential for pharmaceutical success.
At TUODA, we deliver consistently high-quality intermediates trusted by drug manufacturers worldwide. Whether you’re sourcing for early-stage R&D or large-scale production, this guide helps you make informed procurement decisions—efficiently and confidently.
Table of Contents
Chapter 1
What Are Pharmaceutical Intermediates?

Pharmaceutical intermediates are chemical compounds that serve as precursors or processing agents in the multi-step synthesis of active pharmaceutical ingredients (APIs). They are not final drugs themselves but play a vital role in defining the purity, efficacy, and yield of the finished product. These intermediates undergo strict quality control to ensure low impurities, high stability, and batch-to-batch reproducibility.
TUODA specializes in providing pharmaceutical intermediates that meet the requirements of both generic and innovative drug production. Our products are widely used in the synthesis of CNS drugs, cardiovascular compounds, anti-infectives, and oncology APIs. Whether for R&D trials or commercial-scale manufacturing, TUODA ensures reliable global supply with full documentation (CoA, MSDS, TDS).
Chapter 2
Where Do Intermediates Fit in the Drug Manufacturing Process?
Pharmaceutical intermediates represent the essential middle links in the drug synthesis value chain, connecting basic raw materials (like acids, amines, or halides) to final APIs. The journey from raw feedstocks to medicine often requires 5–12 synthesis steps, and intermediates are used in nearly every one of them.

🧪 Drug Manufacturing Flow:
Stage | Step Description | Input Examples | Output |
---|---|---|---|
1 | Starting Material Input | Benzene, Acetic Acid | Basic chemical frameworks |
2 | Initial Intermediate Formation | Halogenation, acylation, amination | N,N-Diethylacetamide |
3 | Advanced Intermediate Coupling | Grignard, reductive amination | 3,5-Dimethylpiperidine |
4 | Final API Assembly | Cyclization, hydroxylation | API such as Ranitidine |
5 | Formulation and Final Dosage Form | Tablets, capsules | Drug product |
🧬 Why It Matters:
Impurities, instability, or variations in intermediates can propagate to the API, jeopardizing drug safety, efficacy, and even market approval.
Chapter 3
Global Trends Shaping the Pharmaceutical Intermediates Market
As regulatory scrutiny intensifies, pharmaceutical manufacturers are restructuring intermediate sourcing strategies toward quality integration, environmental responsibility, and strategic outsourcing.

🌐 Strategic Industry Transformations
CDMO Integration
- 73% of pharma companies now engage CDMOs during candidate selection
- Vertical integration expanding from intermediates through API production
- Performance-based contracts with quality-linked milestone payments
Quality by Design Implementation
- Critical quality attributes identified during intermediate development
- Process parameter ranges established for consistent quality
- Real-time monitoring replacing end-product testing
Supply Chain Globalization
Region | Market Share | Specialization | Trajectory |
---|---|---|---|
China | 42% | Cost-effective heterocyclics | Shifting to higher-value |
India | 28% | Complex chiral, steroids | Expanding compliance |
Western Europe | 14% | GMP-grade advanced | Focusing on high-potency |
North America | 11% | Patent-protected | Strategic reshoring |
Environmental Sustainability
Replacement of chlorinated solvents with cyclopentyl methyl ether and 2-MeTHF
Transition metal catalysts reducing steps by 30–50%
Continuous flow systems reducing solvent usage by 80%
TUODA aligns with these trends through integrated production, full documentation (CoA, MSDS, TDS), and environmental stewardship in accordance with ISO and REACH standards.
Chapter 4
Classification of Pharmaceutical Intermediates
Pharmaceutical intermediates are not one-size-fits-all. Based on their role and position in the synthesis chain, they are typically categorized as follows:
Category | Description | Example |
---|---|---|
Early-Stage Intermediates | Formed during the first few steps of synthesis; often simpler molecules | Benzyl chloride, Methyl 4-nitrobenzoate |
Advanced Intermediates | Structurally closer to the final API and often determine chirality, reactivity | 4-Methylmorpholine, TEMDA |
Chiral Intermediates | Contain stereocenters and are key in enantiopure API synthesis | (R)-Epichlorohydrin, (S)-Proline |
Custom Intermediates | Made-to-order molecules for novel APIs or NCEs | TUODA CDMO-developed molecules |
Not all intermediates serve the same role — choosing the right class, from early-stage to advanced or chiral, ensures efficiency, regulatory alignment, and target-specific performance. Understanding these distinctions empowers procurement teams to align chemical selection with formulation goals and regulatory pathways.
Chapter 5
How to Evaluate Purity, Stability, and Batch Consistency
Pharmaceutical intermediates must meet stringent standards to ensure safe, reproducible synthesis. Purity, thermal stability, and batch uniformity directly influence API quality and regulatory compliance.

Parameter | Why It Matters | Typical Specification |
---|---|---|
Purity (%) | Impurities can affect yield, color, toxicity, and by-products | ≥99.0% (GC or HPLC verified) |
Thermal Stability | Impacts shelf life and reaction consistency | TGA analysis, ≥100°C decomposition temp |
Batch-to-Batch Consistency | Prevents synthesis deviation in scale-up | Relative SD ≤1.5% across 3 lots |
Even minor deviations in purity, thermal resistance, or batch reproducibility can compromise downstream synthesis. For instance:
• Subpar purity increases risk of color shifts, unwanted by-products, and higher rejection rates in QA.
• Low thermal stability can cause premature degradation, affecting shelf life or reactivity.
• Inconsistent batches often lead to scale-up failures and require costly revalidation
That’s why pharmaceutical buyers should always request analytical reports (COA, HPLC, TGA) and review historical batch performance before purchasing.
Chapter 6
Selecting the Right Intermediate for Your Synthesis Route
Each synthesis route has unique structural and reactivity needs. Choosing the wrong intermediate can increase steps, reduce yield, or cause regulatory failure.

Synthesis Type | Preferred Intermediate Type | Example |
---|---|---|
Grignard or Alkylation | Early-stage building blocks | N,N-Diethylacetamide |
Reductive Amination | Enamine-compatible amines | 3,5-Dimethylpiperidine |
Chiral Synthesis | Optical-pure intermediates | (R)-Epichlorohydrin |
Ring Closure / Cyclization | Nitrogen heterocycles | 4-Methylmorpholine |
Chapter 7
Key Packaging, Labeling, and Storage Considerations
Improper packaging or labeling can lead to contamination, misidentification, or customs delay. Storage conditions also affect intermediate lifespan.

UN-Certified Drums for Safe Liquid Storage
HDPE drums with UN certification ensure safe, leak-proof transportation of liquid intermediates. Ideal for hazardous or moisture-sensitive compounds.

Double-Bag Aluminum Foil for Solid Intermediates
Moisture-resistant aluminum foil pouches with double-bag inner lining are used to preserve stability and avoid contamination of solid intermediates.

IBC Totes Ready for Global Distribution
Stackable Intermediate Bulk Containers (IBCs) are used for bulk liquid shipments, optimizing volume efficiency and reducing transport costs.

Controlled Cold Storage for Temperature-Sensitive Goods
Climate-controlled warehouse zones (-20°C, 2–8°C, or ambient) ensure that temperature-sensitive intermediates maintain potency and shelf life.
Chapter 8
How We Ensure Supply Chain Continuity & On-Time Delivery
In pharmaceutical manufacturing, any delay in intermediate delivery can halt your entire production line. At TUODA, we’ve built a resilient, export-ready supply system to ensure your materials arrive on time, in full, and with full documentation. With multi-site production, real-time inventory control, and global shipping experience, we keep your supply chain moving—reliably and efficiently.

Two Manufacturing Sites, Built-In Continuity
Production facilities in Jiangxi and Fujian provide location flexibility and uninterrupted output—even in peak or emergency conditions.
ERP-Linked Real-Time Inventory
Our advanced ERP system lets us track lot status, stock availability, and production progress in real-time. This enables fast response and reliable delivery planning.
Export Experience Across 25+ Countries
From Asia to Europe and Latin America, our global logistics network ensures smooth delivery and customs clearance—no matter your destination.
Full Regulatory Documentation, Always Ready
Every shipment includes COA, MSDS, CIQ, packing list, and customs files, meeting GMP, REACH, and local compliance for pharmaceutical imports.
Flexible Shipping Options with Tracking
Choose sea freight, air cargo, or courier express based on your urgency and budget. All methods include real-time tracking and delivery updates.
“Since switching to TUODA, we’ve never missed a batch deadline due to logistics. Their dual-factory setup and documentation accuracy are unmatched.”
— Procurement Director, EU-based Pharma Group
Chapter 9
TUODA’s Custom Synthesis Capabilities and Product Range
No two drug projects are exactly alike. Many require non-standard intermediates or modifications to meet route-specific, impurity-sensitive, or IP-protected requirements. TUODA offers flexible, client-driven custom synthesis services backed by a strong R&D center in Jinan and ISO-standard production bases in Jiangxi and Fujian.

Customization Scope | What We Offer |
---|---|
Structural Design | Route-based modification of known intermediates |
Process Development | Lab-scale to kilo-scale process optimization |
Scale-Up & Production | Batch sizes from 1kg to multi-ton, validated across sites |
Analytical Support | Full analytical package (HPLC, GC, MS, NMR, IR) |
Confidentiality & IP Protection | Strict project-level NDAs and restricted access protocols |
Chapter 10
Quality Standards & Regulatory Certifications We Meet
Quality isn’t merely a feature at TUODA—it’s our foundation. Our manufacturing facilities operate under stringent quality management systems aligned with international standards:

ISO 9001: Quality Management | Standardized quality management systems | Consistent production, stable documentation |
---|---|---|
ISO 14001: Environmental Management | Sustainable production operations | Eco-friendly and regulatory-compliant manufacturing |
REACH & GHS Safety Labels | EU chemical regulation compliance | Safe, compliant labeling for global shipments |
QC Analytical Methods | HPLC, GC, NMR, FTIR, UV, TGA testing | High-accuracy identity, purity, and stability results |
Batch Traceability | Unique lot ID for every shipment | Ensures full traceability and audit trail |
Our facilities are regularly audited by multinational pharmaceutical clients, maintaining our status as a qualified supplier to regulated markets worldwide.
TUODA maintains comprehensive documentation and third-party certifications across all product categories, ensuring global regulatory compliance and providing customers with complete technical information packages.
Chapter 11
How We Support Your Regulatory Filing (DMFs, COA, MSDS)
Regulatory compliance is critical in pharmaceutical development. TUODA provides comprehensive documentation support to streamline your filing processes:
Document Type | Details Provided | Purpose |
---|---|---|
Certificate of Analysis (COA) | Full specifications and test results | Quality verification |
MSDS/SDS | Available in multiple languages | Safety compliance |
TSE/BSE declarations | Origin confirmation | Regulatory requirement |
Elemental impurity profiles | According to ICH Q3D guidelines | Safety assessment |
Stability data | Supporting storage recommendations | Shelf-life verification |
For products used in regulated applications, we offer Drug Master File (DMF) support including:
- Assistance with Type II DMF filings
- Detailed manufacturing process information (upon confidentiality agreement)
- Historical batch analysis data
- Method validation reports
- Impurity profiles and identification of potential genotoxic impurities
Our regulatory affairs team maintains current knowledge of global requirements, helping you navigate complex compliance landscapes across different markets.
Chapter 12
How We Guarantee the Shipment
TUODA’s logistics excellence ensures catalyst integrity from production to implementation:

Specialized Packaging: Moisture-resistant, inert atmosphere containers with oxygen scavengers
Temperature Monitoring: IoT-enabled tracking devices recording environmental conditions throughout transit
Documentation: Comprehensive certificates of analysis, safety data sheets, and handling instructions
Logistics Expertise: Hazardous materials certified shipping partners with proven track records
Global Network: Strategically positioned distribution centers enabling 98.5% on-time delivery rate
Each shipment undergoes pre-dispatch quality verification and is accompanied by detailed activation protocols to ensure optimal performance upon installation.
Chapter 13
How Pharmaceutical Intermediates Match Your Drug Development Needs
Every pharmaceutical synthesis route has unique structural, regulatory, and performance requirements. Choosing the right intermediate not only ensures chemical compatibility but also improves synthesis efficiency, reduces side reactions, and supports regulatory compliance across different drug categories.
At TUODA, our extensive portfolio of pharmaceutical intermediates covers multiple therapeutic segments and synthesis types—from chiral resolution to heterocyclic ring assembly. The following matrix shows how TUODA products align with key use cases in modern drug development.
Synthesis Route or Application | Recommended Intermediate Type | Key Benefits | Selection Considerations |
---|---|---|---|
Grignard Reactions | N,N,N',N'-Tetramethylethylenediamine (TMEDA) | Chelating agent, improves yield and control | Base strength, metal complexation behavior |
Reductive Amination | 3,5-Dimethylpiperidine | Provides steric control and increased reactivity | Chirality and compatibility with reducing agents |
Heterocycle Synthesis | 4-Methylmorpholine | Excellent nitrogen source, improves stability | Boiling point, reactivity with acids |
Electrophilic Substitution | 2-Methyl-3-trifluoromethylaniline | High electron density for regioselective substitution | Fluorinated group compatibility, handling precautions |
Chapter 14
Our Value-Added Services
TUODA is committed to making your experience seamless through practical services that truly add value:
Pre-Sales Assistance
Fast Response: Inquiries answered within 24 hours by our dedicated sales team
Technical Consultation: Product specialists help select the optimal catalyst for your specific need
Free Samples: Test quantities available for performance verification in your actual conditions
Customized Quotes: Transparent pricing with volume discounts clearly outlined
Documentation Package: Comprehensive product specifications and application guidelines provided upfront
Ordering Flexibility
No Minimum Order: Small quantities available for trials and testing
Sample Orders Welcome: 100g test quantities available with expedited shipping
Flexible Payment Terms: Multiple options to suit your company’s procurement policies
Rush Processing: Expedited handling for urgent requirements
Custom Packaging: Special containment solutions according to your handling requirements
Reliable Delivery
Worldwide Shipping: Established logistics partnerships for delivery to any location
Complete Documentation: Commercial Invoice, Packing List, COA, Health Certificate, and Origin Certificate
Special Requirements: Custom documentation available for specific market regulations
Tracking Updates: Regular shipment status notifications throughout transit
Import Assistance: Guidance on customs procedures for smooth clearance
After-Sales Support
Quality Guarantee: Full replacement policy for any products not meeting specifications
Technical Hotline: Direct access to product specialists for application questions
Usage Guidance: Practical advice on optimal handling and implementation
Feedback Channel: Dedicated system for reporting performance results and suggestions
Reorder Simplification: Streamlined process for repeat purchases with previous specifications
Long-Term Partnership
Regular Check-ins: Scheduled follow-ups to ensure ongoing satisfaction
Product Updates: Information on new developments relevant to your applications
Loyalty Benefits: Preferential terms for established customers
Market Insights: Sharing of relevant industry trends and opportunities
Continuous Improvement: Your feedback directly influences our product development
TUODA makes doing business easy with practical support that addresses your real-world needs at every stage.
Chapter 15
Why Choose TUODA for Pharmaceutical Intermediates?
TUODA offers distinct advantages that position us as your trusted partner in sourcing high-quality pharmaceutical intermediates. From early R&D to commercial-scale production, we ensure technical excellence, regulatory compliance, and global delivery performance.

TUODA Advantage | How We Deliver Value |
---|---|
High Purity Standards | Intermediates ≥99.0% purity, backed by GC/HPLC data and full COA documentation |
Dedicated R&D Support | Custom route development and impurity control supported by expert chemists |
Responsive Client Service | Multilingual team offering 1-on-1 support for sampling, tech docs, and updates |
Reliable Global Supply Chain | Dual production sites + smart inventory ensure continuity and fast turnaround |
Flexible Commercial Terms | Accepts LC, TT, staggered delivery contracts to reduce client pressure |
Regulatory Documentation Ready | COA, MSDS, TDS, and DMF-supporting files provided for each batch |
Custom Intermediate Design | Molecule-level tailoring based on your synthesis or API strategy |
Efficient Production Processes | Streamlined workflows reduce lead times and enhance consistency |
Proven Industry Experience | Over 10 years in pharmaceutical intermediate exports and compliance |
Client-First Commitment | Fast feedback, sample tracking, and dedicated account manager support |
Chapter 16
Lead Times, Samples, Documentation, and MOQ
Choosing the right petrochemical catalyst supplier can significantly impact your operational efficiency, cost-effectiveness, and product quality. Here are essential considerations when sourcing industrial catalysts:

1. Quality Assurance & Certification
Ensure your supplier adheres to internationally recognized standards, such as ISO 9001, guaranteeing consistent quality, purity, and reliable performance.
2. Catalyst Performance & Selectivity
Evaluate catalyst selectivity, activity levels, and reaction efficiency to confirm alignment with your specific industrial applications, such as polymerization, refining, or specialty chemical synthesis.
3. Customization Capability
Confirm whether the supplier offers tailored catalyst solutions and formulations customized to your production processes and technical requirements.
4. Supply Stability & Production Capacity
Choose suppliers like TUODA that maintain robust manufacturing facilities and multiple production bases, ensuring uninterrupted supply and rapid delivery.
5. Technical Expertise & Support
Prioritize suppliers providing professional consultation, on-site technical guidance, and proactive after-sales support, maximizing catalyst performance and lifespan.
6. Environmental Responsibility
Select partners committed to sustainable manufacturing practices, minimizing environmental impact through recyclable packaging, catalyst regeneration services, and compliance with environmental standards.
Choose TUODA – Your Trusted Partner in Petrochemical Catalysts.
Chapter 17
Lead Times, Samples, Documentation, and MOQ
In today’s fast-paced pharmaceutical market, efficient procurement is crucial. Below you’ll find answers to common questions that help you understand lead times, sample availability, documentation details, and minimum order requirements for pharmaceutical intermediates—ensuring you make confident, informed purchasing decisions.



1. Can I request a sample before placing a bulk order?
Yes, we offer sample testing support. You can order up to 100g of most intermediates as a sample. Samples undergo quality testing to verify purity before shipment, ensuring you receive a product that meets your expectations. Shipping costs are typically borne by the buyer.
2. What is the Minimum Order Quantity (MOQ)?
Our standard MOQ is 1kg, though we accommodate smaller quantities (down to 100g) for R&D or pilot projects when the sample charge is 100% prepaid. This flexibility allows you to evaluate the product before scaling up.
3. What documentation accompanies each shipment?
We provide a complete set of export-ready documents to meet regulatory and customs requirements. This includes:
- Commercial Invoice
- Packing List
- Bill of Lading
- Certificate of Analysis (COA)
- Health Certificate
- Certificate of Origin
If your market requires additional documentation, simply let us know.
4. What are your typical lead times and shipping methods?
Lead Times:
- In-stock items: 3–7 days
- Custom synthesis or non-stock items: 2–4 weeks
Shipping Methods:
- ≤50kg: Express delivery (DDU/DHL/FedEx)
- 50–500kg: Air freight (FOB/CFR)
- 500kg: Sea shipping (FOB/CIF)
For high-value products, we recommend air or express shipping for enhanced security and speed.
After-Sales Service:
We monitor logistics in real-time and offer ongoing support. If any product issues arise, you can return or consult with our service team for prompt resolution.
Chapter 18
In Summary: TUODA’s Commitment to Pharmaceutical Intermediate Excellence
At TUODA Industry Limited, excellence is not optional—it’s our standard. Backed by cutting-edge R&D in Jinan and GMP-aligned production sites in Jiangxi and Fujian, we provide global pharmaceutical clients with high-purity, compliant, and consistent intermediates that meet the demands of modern drug manufacturing.
Why Clients Trust TUODA:
• Consistent Quality:
ISO 9001-certified systems and rigorous QC protocols ensure batch-to-batch reliability.
• Custom Synthesis Solutions:
One-stop support for tailored intermediates that fit your synthesis route and regulatory requirements.
• Reliable Global Supply:
98.5% on-time delivery rate, with flexible logistics and export-ready documentation.
• Regulatory Support:
Full technical files (COA, MSDS, DMF support) to assist your filings and audits.
• Sustainable Production:
Environmental responsibility integrated into every stage of production and packaging.
Partner with TUODA – Trusted by formulators worldwide for quality, agility, and long-term success.
Let’s build your next breakthrough, one intermediate at a time.
Get a Free Quote
Contact us today to receive a free quote and expert consultation on chemical intermediates and petrochemical solutions. Tuoda is ready to provide the perfect solution for your project.
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Tell Us What You Need
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Approve for Mass Production
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Get the Best Solution
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